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Figure 1 shows the degree of inhibition by FP, at varying concentrations 10-10 to 10-6 M ; , of PHAinduced proliferation of peripheral blood CD4 + T lymphocytes, isolated from individuals in each of the three clinical groups studied. These results show an almost complete suppression of CD4 + T-lymphocyte thymidine uptake after PHA-stimulation in SSA and non-asthmatic control subjects at a concentration of 10-9 M FP. Also, the mean IC values for SSA 30 and non-asthmatic subjects are lower than that for SRA patients Table 1 ; . In CD4 + T cells from SRA patients, there was a reduction of only about 70% at 10-8 M concentration, with no further reduction even at 10-6 M, compared to a reduction of about 95% in SSA patients and non-asthmatics Table 2 ; . In contrast, the suppression of thymidine uptake by FP in CD8 + T cells was identical in the three clinical groups. Absolute suppression of thymidine uptake was most consistent with the pattern seen in the CD4 + T cells from the SRA group Figure 2 ; . The IC values of the three groups were around 30.
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