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Used in studies of the headache substances. The uterus from a 200 Gm. virgin female rat was removed after death by ether anesthesia and suspended in modified RingerLocke's solution at a temperature of 29 C. One end was attached to a lever for writing on a smoked drum. The contractibility of the preparation was ascertained by adding 1 cc. of a solution of acetylcholine containing 1 .g. per cc. of acetylcholine. In suitable rat uterus preparations this concentration of acetylcholine predictably produced good quality rhythmic contractions. Eight experiments were performed with saline extracts of extracranial subsurface tissue fluid utilizing this rat uterus preparation. The fluid removed from a headache subject during a headache-free interval and from one subject on two occasions ; who "never had a headache" induced no contractions. On one occasion, fluid removed from a headache-free side, for instance, puva.
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Received February 17, 2003; first decision March 10, 2003; revision accepted March 13, 2003. From the Department of Medicine and Molecular Science M.K., K.No., S.S., K.Na., K.C. ; , Department of Cardiovascular Physiology and Medicine Y.H., M.Y. ; , Division of Physical Therapy, Institute of Health Sciences C.G. ; , and Department of Clinical Laboratory Medicine T.O. ; , Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan. Correspondence to Dr Yukihito Higashi, Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Mimami-ku, Hiroshima 734-8551, Japan. E-mail yhigashi hiroshima-u.ac.jp 2003 American Heart Association, Inc. Hypertension is available at : hypertensionaha DOI: 10.1161 01.HYP.0000068202.42431 and reglan, for instance, oxsoralen lotion.
Identification of factors which interact with the calcium response element of human keratin 1 and analysis of its functional role Y Kawachi, 1 F Otsuka1 and DR Roop2 1 Dermatology, University of Tsukuba, Tsukuba, Ibaraki, Japan and 2 Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX We have previously identified a functional calcium responsive element CaRE ; , 3 of the human K1 gene that consists of a composite AP-1 steroid hormone element. In the present study we demonstrate that in a low calcium environment, when the CaRE is unable to activate a target promoter, the AP-1 site is occupied by either c-Jun or JunB and the hormone response element is bound by COUP. Overexpression of c-Jun, or COUP in primary keratinocyte cultures cotransfected with a CaRE reporter construct specifically suppressed calcium activation of the promoter by the CaRE. In contrast, we found that overexpression of c-Fos in primary keratinocytes activated the CaRE reporter construct in the absence of calcium while c-Jun, JunB or JunD did not. These results suggest that Jun and COUP bind to the CaRE in undifferentiated keratinocytes to suppress transcription of HK1. Upon initiation of differentiation, c-Fos displaces Jun from the CaRE to activate expression of K1 in post-mitotic keratinocytes. Glutathione S-transferase pull down assay demonstrated the direct binding of COUP to c-Jun and c-Fos in vitro. The binding affinity of COUP to c-Jun seemed to be higher than that to c-Fos, suggesting that COUP and c-Jun can cooperatively suppress the expression of HK1 in undifferentiated keratinocytes via their direct interaction. Taken together, these data provide evidence for both physical and functional interactions among COUP and AP-1 factors during differentiation of keratinocytes.
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17. PETITION # 9033 BY JOSEPH RAUCH to change the zoning from R-1 Residential to R-2 Residential on property located at 4552 Vilas Road in part of the W 1 2 Section 6, Town of Cottage Grove. IN FAVOR: Joseph Rauch OPPOSED: None STAFF: P&D, HWY, EH TOWN: Town approved, no conditons Motion by Pertzborn Wendt to approve; carried, 4-0. 18. PETITION # 9034 by ZOOS LAND COMPANY to change the zoning from A-1 EX Exclusive Agriculture to R-1 Residential on property located West of 1068 US Highway 12&18 in part of the SE 1 4 Section 29, Town of Deerfield. Motion by Pertzborn Jensen to table until the end of the public hearing; carried, 4-0. Motion by Jensen Pertzborn to take off the table; carried, 4-0. IN FAVOR: None OPPOSED: None STAFF: P&D, HWY, EH TOWN: No Town action Motion by Pertzborn Wendt to postpone; carried, 4-0. 19. PETITION # 9035 BY KERRY DUNN & VICTORIA EHERENMANN-DUNN to change the zoning from A-1 EX Exclusive Agricultural to R-3 Residential on property located at 4212 Sprecher Road in part of the NE 1 4 Section 14, Town of Blooming Grove. IN FAVOR: Kerry Dunn OPPOSED: STAFF: P&D, HWY, EH TOWN: No Town action Motion by Jensen Wendt to postpone; carried, 4-0. 20. PETITION # 9036 BY PAUL & DAWN BARTELL to change the zoning from A-2 1 ; Agricultural to R-1A Residential and B-1 Local Business on property located at 4877 County Highway N in part of the NE 1 4 Section 33, Town of Sun Prairie. IN FAVOR: Dennis Richardson OPPOSED: None STAFF: P&D, HWY, EH TOWN: Town approved, with conditons Motion by Jensen Wendt to approve with the following conditons; carried, as amended, 4-0. 1 ; Deed restriction limiting the use of the B-1 property exclusively to retail sales or retail service businesses including related services but not including sales, servicing or repair of motor vehicles or any business or service for which the items offered for sale or which require service are stored, parked or displayed outside of a building, except as provided by this ordinance; Deed restriction limiting the hours of operation on the B-1 property of any business to 6 A.M. to 9 P.M and naprelan.
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