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Randomized Trial Comparing the Use of Nasal Continuous Positive Airway Pressure nCPAP ; to Synchronized Nasal Non-Invasive Positive Pressure Support sNIPP ; in Preterm Infants Aaron Chiu, Jubara Alallah, John Minski, William Petranick, Ruben Alvaro. Pediatrics, University of Manitoba, Winnipeg, MB, Canada; Medical Rehabilitation, University of Manitoba, Winnipeg, MB, Canada; Respiratory Medicine, St Boniface Hospital, Winnipeg, MB, Canada.
HUFF, Murray W MARETTE, Andr BROSNAN, John Sean ; T BROSNAN, Margaret E CIANFLONE, Katherine M COHN, Jeffrey S DESHAIES, Yves GIACCA, Adria HALPERIN, Mitchell L HOFFER, Leonard J Robarts Research Institute Centre hospitalier de l'Universit Laval Memorial University of Newfoundland Memorial University of Newfoundland Royal Victoria Hospital Universit de Montral Universit Laval University of Toronto University of Toronto Sir Mortimer B. Davis Jewish General Hospital JONES, Glenville KIEFFER, Timothy J KORBUTT, Gregory S KOSCHINSKY, Marlys L LEWIS, Gary F MARETTE, Andr SCOTT, Fraser W SORISKY, Alexander M STEINBRECHER, Urs P VERCHERE, Cameron B WING, Simon S Queen's University University of British Columbia University of Alberta Queen's University University of Toronto Centre hospitalier de l'Universit Laval Ottawa Health Research Institute University of Ottawa University of British Columbia University of British Columbia McGill University, for example, pharmacist.
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Weekly Charity work in Al- Hussein Polyclinic in Saida since 1992 present * Interview on "NBN Television "on the Health morning program, A National Health Program, sessions, discussing "Smoking, Side effect and sessation".2001. * Interview on "ART International" on Invasive and non invasive Modalities in Diagnosis and Treatment of CAD. 2001. * Interview on Al- Ahram Magazine. Science and Medicine section, on Hypertension New modalities of treatments and guidelines. Interview done by Journalist Hatem Sudki.2005 Service to the Profession * Co- Chairman of the scientific Committee of the syndicate of The Lebanese order of Physician, 2005- present. * Co-Chairman of the Ethical Committee of the Syndicate of the Lebanese Order of Physician, 2005- present. * Member of the American Society of Echocardiography- 1996 -present * Member of the Heart Failure Society of America- 2003- present * Fellow of the European Society of Cardiology- 2003- present * Member of the New York Academy of Sciences- 2002- present * Member of the syndicate of The Lebanese Order of Physician, 2004- present * Vice president of the Syndicate of the Lebanese Order of Physician, 2004 -2005 * Member of The Lebanese Cardiac Society. 1992- Present * Member of the Lebanese Cardiac Society Working Groups on Echocardiography and Heart Failure. 2002- present * Moderator of the Journal Club of the Lebanese Cardiac Society.2001-2003 * Member of the Lebanese Committee for Colloquium Exam- 1992-present.
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Each year, according to the Pulmonary Fibrosis Foundation. The disease typically strikes people in their 50s or above, causing severe scarring of the lungs, with death usually occurring about three years after diagnosis. There is no cure for IPF except lung transplantation. The cause might be a combination of genetic susceptibility and environmental influences such as smoking, Dr. Garcia said. About one in 50 IPF patients, or approximately 2 percent, have an inherited form of the disease, Dr. Garcia said, and it's this genetic link that she and her colleagues focused on. "We don't have a handle yet on all the genes that cause the majority of the cases, but this is a start, " she said. Telomerase is an enzyme that controls the lengths of DNA at the ends of chromosomes, called telomeres. In normal cells, where telomerase is inactive, telomeres shorten each time the cell divides. When they reach a certain length, the cell stops dividing. In stem cells and in most cancerous cells, however, telomerase is active, and the telomeres don't shorten during cell division, allowing the cells to remain effectively immortal. During the study, the researchers examined members of 46 families with two or more cases of lung scarring, and used two of the largest families to conduct a genetic hunt for the gene responsible. They identified a gene called TERT, which codes for one portion of the telomerase enzyme. It was in this gene that the researchers identified mutations in the two large families as well as in four other families. Many of the people with TERT mutations had symptoms of IPF, but some did not, which suggests environmental factors may contribute to the deadly lung disease. Furthermore, one mutation in a gene called TERC, which codes for a second portion of telomerase, was found. The researchers observed that all of the study subjects who carried any mutations in TERT or TERC had a deficiency in telomerase that led to shortened telomeres, even those who did not have evidence of lung scarring. The researchers also found that people with the mutations often had other diseases, such as anemia and osteoporosis, suggesting that these mutations affect telomerase function in not only the lungs, but also in other organ systems. By screening 44 patients with sporadic IPF, the researchers found one additional mutation in TERT, supporting the conclusion that TERT mutations might be involved in some cases of the more common noninherited form of the disease. News-Medical News, 29 April 2007 : news-medical.
Tribulova N.1, Fialova M.1, Knezl V.2, Dlugosova K.1, Hailin H.3, Imanaga I.3, Okruhlicova L.1 1 Inst. Heart Res.; 2Inst. Exp. Pharmacol., SAS, Bratislava, Slovakia; 3Dept. Physiol. Fukuoka Univ., Fukuoka, Japan; narcisa.tribulova savba.sk Aims: Functional electrical and metabolic communication at the gap junction connexin channels ensures myocardial synchronisation, while connexin abnormalities are thought to be arrhythmogenic. We examined, therefore, topology, expression and phosphorylation of connexin-43 Cx43 ; as well as susceptibility of the heart to ventricular fibrillation VF ; in various models of cardiomyopathy. Methods: Experiments were conducted on male adult spontaneously hypertensive rat, STZ-diabetic rat and hyperthyroid rat hearts. Distribution of Cx43, its expression and phosphorylation were analysed using immunodetection and Western blotting with mouse MAb. Susceptibility to VF was examined in isolated heart preparation using electrical stimulation or hypokalemic perfusion. Results: Immunodetection revealed besides end-to-end intercalated disc-related ; enhanced expression of side-to-side Cx43 positive gap junctions in hypertensive and hyperthyroid rat hearts. In addition, total Cx43 and its phosphorylated isoforms were significantly decreased in hyperthyroid and hypertensive, while increased in diabetic rat hearts. In correlation diabetic rats were less while hypertensive and hyperthyroid rats much more prone to develop VF. Interestingly, susceptibility to VF was increased in diabetic rats treated with thyroid hormone that was linked with suppression of Cx43 expression and phosphorylation. Conclusions: These findings indicate that intercellular channel protein Cx43 is involved in the modulation of susceptibility of the heart to malignant arrhythmias. Abnormal distribution and down-regulation of Cx43 increase a risk for VF. Supported by APVV grants 51-059505 and 51-015905 and lasix.
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Restenosis remains a major challenge, limiting the clinical efficacy of coronary angioplasty. Vessel elastic recoil, constrictive remodelling and neointimal hyperplasia all contribute to the process of restenosis. Compared with coronary balloon angioplasty alone, stent implantation can improve early and late outcomes. Coronary stenting can, at least partially, prevent elastic recoil and negative remodelling but is hampered by an increased neointimal hyperplastia, causing in-stent restenosis. Stent implantation causes deep arterial injury and provokes a pronounced tissue response. Mural thrombi, inflammatory response, smooth muscle cell SMC ; migration and proliferation and extracellular matrix formation all contribute to the pathogenesis of neointimal hyperplasia. Systemic pharmacological approaches to prevent in-stent restenosis have shown little benefit in most clinical trials. Low drug concentration at the target site may be the major reason for these failures. Drug-eluting stents have been proposed as an alternative approach to decrease neointimal hyperplasia. Polymer-coated stents can serve as a reservoir for local drug delivery. Preclinical studies have demonstrated the feasibility and efficacy of this approach, and preliminary results of on-going clinical trials are very promising, for example, cortisone injections.
Table 1 Comparison of the Results between the Partial and Complete Obstruction Groups Group Partial Complete Total P value Total Cases 239 191 430 Technical Failure 7 13 20 * Initial Success 150 62.8 ; 97 50.8 ; 247 57.4 ; .014 * Mean Patency mo ; 23.8 25.7 26.6 Table 2 Comparison of the Results of Various Anatomic Sites of Obstruction Site Canaliculus Sac Junction Duct P value Total Cases 275 41 56 Technical Failure 19 1 0 Initial Success 155 56.4 ; 21 51.2 ; 23 41.1 ; 48 82.8 ; .001 * Mean Patency mo ; 25.8 4.6 10.7 much longer than that of the 5-minute group Table 4 and meridia.
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University of Toronto, Dept. of Surgery, Toronto, Canada Primary treatment for esophageal achalasia remains controversial. Advocates of surgical myotomy cite perforation and difficult subsequent operation as disadvantages of pneumatic dilation. This report documents the results and findings of surgery for perforation following pneumatic dilation. Between 1962 and 1986 223 patients with esophageal achalasia were treated primarily with pneumatic dilation. Perforation was sustained in 7 patients. Of these, 6 were operated upon urgently, the tear repaired, myotomy completed and an anti-ref lux procedure performed. There were no mortalities in this group and follow-up 1-24 years ; by interview and radiology shows excellent functional results. Perforation treated conservatively in one patient was unsuccessful and required delayed thoracotomy with ultimate excellent functional results. No undue technical difficulties at surgery were encountered attributable to dilation. We conclude that pneumatic dilation can be attempted primarily in most patients with achalasia. In the small group where this results in perforation, immediate surgery is indicated with the expectation of a technically straightforward procedure and excellent long term results unaffected by previous pneumatic dilation. treatment We for do not advocate perforation. conservative.
A new VAT Law in accordance with the principles of EU Directives is effective from 1 May 2004. The following transactions are subject to Estonian VAT: taxable supply of goods and services the place of supply of which is Estonia taxable import of goods; taxable intra-Community acquisitions of goods. The standard VAT rate is 18%. The reduced rate of 5% applies to books, periodicals, hotel accommodation services, certain listed medicines and medical equipment and the treatment of dangerous waste. The VAT rate on the export of goods and certain services is 0% i.e. exemption with credit ; . Some supplies would be exempt i.e. exemption without credit ; , such as medical services, banking and insurance and naprosyn.
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