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L. Dang 1 , M. Rotter 2 , N. Virag 3 , V. Jacquemet 4 , L. Kappenberger 5 , M. Haissaguerre 2 . 1 EPFL, Signal Processing Institute, Lausanne, Switzerland; 2 Hospital du Haut-Leveque, Bordeaux, Pessac, France; 3 Medtronic S.A., Tolochenaz, Switzerland; 4 EPFL, Signal Processing Institute, Lausanne, Switzerland; 5 CHUV, Lausanne, Switzerland Introduction: Pulmonary vein isolation PVI ; is commonly used to treat atrial fibrillation AF ; . Increasing the size of the isolated area possibly eliminates more foci and prevents them to trigger sustain AF. However larger isolated areas may be a substrate for atrial flutter AFL ; by creating narrow conduction isthmuses or anchoring sites. In a computer model of AF, we studied the impact of excluded atrial tissue surface on incidence of atrial flutter. Methods: A biophysical model of AF using an anatomical geometry of the atria based on human MR images and a membrane kinetics model were used. Ablation lines were modeled by assigning non conductive properties to the cardiac units along the ablation lines. PVI was implemented in different patterns with increasing surface of excluded tissue: i ; Individual PVI 5 mm from ostia 10 cm2 excluded area ii ; Individual PVI 7.5 mm from ostia 17 cm2 excluded area iii ; Individual PVI 10 mm from ostia 26 cm2 excluded area ; virtually resulting in posterior LA isolation; iv ; 2x2 PVI 5 mm from ostia 18 cm2 excluded area ; . AF was initiated using burst pacing. Following 30 different initial states during sustained AF, ablation was performed for each combination pattern. Results: The table summarizes the percentage of simulations ending either in sinus rhythm SR ; or in persistent AF and AFL. Pattern ii ; and iv ; showed higher SR conversion; however with an increased incidence of AFL. A further increase in ablated area, pattern iii ; , resulted in a high success rate of 60% but low incidence of AFL 10% ; due to coalescent lesions on the posterior LA surface. Secondary teachers you will be seeing your schedule along with your department's schedule ; before the end of the year. If you do not agree with your schedule or do not believe that schedules within your department are equitable, then do not sign off and write your reasons in the comments space provided on the form. Administration will have to sit down with me and we will look for solutions. Similarly, you must be asked and voluntarily agree if you are going to teach more than 3 preps next year. Secondary principals have these forms. I'd like to thank the retirees for their years of outstanding service to Brighton students. Your work has improved our world. We will miss you, and we wish you well in retirement. Have a great summer! Respectfully. [a] G. Gerebtzoff, X. Li-Blatter, Dr. A. Seelig Biophysical Chemistry, Biozentrum, University of Basel Klingelbergstrasse 70, 4056 Basel Switzerland ; Fax: + 41 ; 61-267-21-89 E-mail: anna elig unibas.ch [b] Dr. H. Fischer Present address: F. HoffmannLa Roche Ltd. Pharma Research, Molecular Properties Grenzacherstrasse, 4070 Basel Switzerland ; [c] Dr. A. Frentzel Present Address: Mepha Pharma Dornacherstrasse 14, 4147 Aesch Switzerland.

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